The role of MicroRNA signature as diagnostic biomarkers in different clinical stages of colorectal cancer

Objective: Colorectal cancer (CRC) is one of the most common cancers and a major cause of cancer-related death worldwide. The early diagnosis of colorectal tumors is one of the most important challenges in cancer management. MicroRNAs (miRNAs) have provided new insight into CRC development and have been suggested as reliable and stable biomarkers for diagnosis and prognosis. The aim of this study was to analyze the differential expression of miRNAs at different stages of CRC searching for possible correlation with clinicopathological features to examine their potential value as diagnostic biomarkers. Materials and Methods: In this case-control study, plasma and matched tissue samples were collected from 74 CRC patients at stage II-IV as well as blood samples from 32 healthy controls. After exhaustive study of the current literature, eight miRNAs including miR-200c, 20a, 21, 31,135b, 133b,145 and let-7g were selected. The expression level of the miRNAs was assayed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Statistical analysis, including t test , Mann-Whitney U, Kruskall-Wallis tests and receiver operating characteristic (ROC) curve was applied, where needed. Results: Significantly elevated levels of miR-21, miR-31, miR-20a, miR-135b, and decreased levels of miR-200c, miR-145 and let-7 g were detected in both plasma and matched tissue samples compared to the healthy group (P0.05). ROC for tissue miRNAs showed an area under the ROC curve (AUC) of 0.98 and P<0.001 for miR-21, 0.91 and P<0.001 for miR-135b, 0.91 and P<0.001 for miR-31, and 0.92 and P<0.001 for miR-20a. Conclusion: Our results indicate that the expression levels of microRNAs are systematically altered in CRC tissue and plasma. In conclusion, detection of miR-21, miR-135b, miR-31 and miR-20a levels in the tissue might be helpful to illuminate the molecular mechanisms underlying CRC carcinogenesis and serve as tumor-associated biomarkers for diagnosis. © 2018 Royan Institute (ACECR). All Rights Reserved

Exploring industrial community energy systems: A missing link in the industrial energy transition?

The transition to renewable energy sources affects all sectors of society, including the industrial sector. Besides climate policy ambitions and other concerns regarding the social and environmental acceptability of energy provision, the transition to renewables may also improve the availability and affordability of energy services. The latter holds especially in some developing countries, where the development of energy infrastructure often lags behind the needs of industry. For many industries, the energy transition challenge entails the future substitution of high temperature, fossil-fired processes to lower temperature e.g., electrochemical conversion routes, which will make them much more than now depend on the reliable and affordable provision of electricity. However, in many developing economies, even the current provision of electricity is far from reliable. Transitioning to power generation from renewable energy (RE) sources can contribute to a more diversified, resilient, and environmentally-friendly power generation mix.If the energy sector in developing economies does not sufficiently invest in a robust generation mix for the future, industry itself may consider to take the lead. For individual companies, however, especially small and medium-sized enterprises (SME), the high upfront investment costs of infrastructure for harvesting and transporting renewable energy present a significant hurdle. Inspired by the literature on community energy systems (CES) and industrial symbiosis (IS), this thesis set out to investigate if, and under which conditions, industrial companies may be willing to join forces in industrial community energy systems (InCES) in order to secure their supply of electricity from renewable energy sources.Energie and Industri

Exploring industrial community energy systems: A missing link in the industrial energy transition?

The transition to renewable energy sources affects all sectors of society, including the industrial sector. Besides climate policy ambitions and other concerns regarding the social and environmental acceptability of energy provision, the transition to renewables may also improve the availability and affordability of energy services. The latter holds especially in some developing countries, where the development of energy infrastructure often lags behind the needs of industry. For many industries, the energy transition challenge entails the future substitution of high temperature, fossil-fired processes to lower temperature e.g., electrochemical conversion routes, which will make them much more than now depend on the reliable and affordable provision of electricity. However, in many developing economies, even the current provision of electricity is far from reliable. Transitioning to power generation from renewable energy (RE) sources can contribute to a more diversified, resilient, and environmentally-friendly power generation mix.If the energy sector in developing economies does not sufficiently invest in a robust generation mix for the future, industry itself may consider to take the lead. For individual companies, however, especially small and medium-sized enterprises (SME), the high upfront investment costs of infrastructure for harvesting and transporting renewable energy present a significant hurdle. Inspired by the literature on community energy systems (CES) and industrial symbiosis (IS), this thesis set out to investigate if, and under which conditions, industrial companies may be willing to join forces in industrial community energy systems (InCES) in order to secure their supply of electricity from renewable energy sources

Can industries be parties in collective action? Community energy in an Iranian industrial zone

The industrial sector plays a huge role in creating economic growth. While energy is vital for industries to thrive, various factors are undermining the availability of energy including phasing out of fossil fuels, CO2 emission caps and, the large gap between the fast developments of industrial clusters and the energy supply, especially in developing countries. Recently, enabled by renewable energy technologies, a transition process is taking place towards decentralized settings for energy provision where households in neighbourhoods initiate renewable electricity cooperatives. The question addressed in this research is if or to what extent the model of collective action deployed by citizen cooperatives is applicable to collaborations between industries in an industrial cluster. We identified the conditions for the establishment of Industrial Community Energy Systems (InCES) from a collective action perspective by using Ostrom's Institutional Analysis and Development Framework. The case study selected is the industrial city of Arak, one of the largest and most diversified industrial clusters in Iran. Besides desk research, data was also collected by conducting semi-structured interviews and by holding stakeholder workshops. The results of this study highlight the importance of community spirit and trust for the establishment of InCES, unlike citizen cooperatives where finance and environmental attitude are essential. A transparent legal framework to resolve conflicts that might emerge in industrial partnerships is another crucial element given the many differences among industries such as differences in energy demand and in usage patterns.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Energy & IndustryTransport and LogisticsEconomics of Technology and Innovatio

Collaborative Renewable Energy Generation among Industries: The Role of Social Identity, Awareness and Institutional Design

Like many other sectors, climate change strategies have put various restrictions on industry, the most prominent one being caps on CO2 and other energy-related emissions. At the same time, and especially in many developing economies, the industry struggles with an increasing gap between the fast development of the sector and lagging energy supply capacity. Collective generation of renewable energy is seen as a promising means of transition, next to other forms of renewable energy generation (centralised, individual). The aim of this research is to investigate factors influencing willingness to participate in Industrial Community Energy Systems (InCES). Using existing literature on Industrial Symbiosis and Community Energy Systems, we formulate plausible hypotheses on the most relevant factors for the willingness of industries to join such initiatives. As one of the largest and most diversified industrial clusters in Iran, Arak industrial park is selected as the case study. Data were collected from the CEOs of 96 companies through survey research. Our results highlight the crucial role of awareness about the benefits of renewable power generation in an InCES. Social identity among industries and trust between them are also determining factors for their willingness to join InCES. Finally, proper institutional design for overcoming the partnership complexities (e.g., conflict resolution) was highlighted as a crucial factor for industries. It can be concluded from the results of this study that policymakers should avoid one-size-fits-all incentive design approaches and reach out to larger companies with targeted incentives, introduce specially designed bank loans for different target groups, and make use of consulting companies as intermediaries to increase the awareness of the industries regarding the benefits of investing in an InCES.Energy & IndustryTransport and Logistic

Industrial community energy systems: Simulating the role of financial incentives and societal attributes

Considering that the industrial sector consumes almost one-third of the energy demand globally, it is an urgent call to reduce the carbon footprints in this sector. Among different approaches to meet this goal, such as the employment of carbon capture technologies and increasing energy efficiency within industries, transitioning to renewable electricity (RE) would be another outlook to reduce the carbon footprints and increase the energy security of the industries. Collective power generation within communities has shown to be feasible and promising in the industrial sector, where groups of industries collaborate to generate energy and meet their energy demand. In this research, we investigated how the initiation and continuation of industrial community energy systems (InCES) among companies can take place and which financial incentives the government can introduce to support these initiatives. We built an agent-based model that incorporates cost-benefit analysis and cultural factors in the decision making process of industries, to assess the feasibility of initiating/joining an InCES by industries. This study shows that the FIT mechanism had the worst performance in incentivizing the establishment of an InCES among industries. In contrast, the TAX incentive showed the best performance in mobilizing the investments towards InCES. Similarly, the TAX incentive showed relatively superior performance in electricity generation, the number of established InCESs, and the number of companies joining each InCES. Despite the better performance of the TAX incentive, it was also the most expensive option for the governments as a significant share of the establishment costs of an InCES was put on the shoulders of the governments.Energy & IndustryEconomics of Technology and Innovatio